Last edited by Kazrat
Thursday, November 12, 2020 | History

7 edition of Microbial genomics and drug discovery found in the catalog.

Microbial genomics and drug discovery

  • 189 Want to read
  • 38 Currently reading

Published by Marcel Dekker in New York .
Written in English

    Subjects:
  • Antibiotics.,
  • Microbial genetics.,
  • Gene mapping.,
  • Genomics.,
  • Pharmacogenomics.,
  • Drug development.

  • Edition Notes

    Includes bibliographical references and index.

    Statementedited by Thomas J. Dougherty, Steven J. Projan.
    ContributionsDougherty, Thomas J. 1950-, Projan, Steve.
    Classifications
    LC ClassificationsRM267 .M613 2003
    The Physical Object
    Paginationxi, 243 p. :
    Number of Pages243
    ID Numbers
    Open LibraryOL3319340M
    ISBN 100824740416
    LC Control Number2004270533
    OCLC/WorldCa52513079

      Microbial cells are found in abundance in marine sediments beneath the ocean and make up a significant amount of the total microbial biomass on the planet. Microbes found deeper in the ocean, such as in hydrocarbon seeps, are usually believed to have slow population turnover rates and low amounts of available energy, where the further down a. Stanford Libraries' official online search tool for books, media, journals, databases, government documents and more. Microbial genomes in SearchWorks catalog Skip to search Skip to main content. Common challenges. Ever-growing sample volumes demand efficient bioinformatics. Yet a lack of well integrated analytics for microbial genomics leaves researchers and organisations with the burden of integrating and maintaining all the required bioinformatics-, statistics- and visualisation tools required to power their research. Drug Discovery and Development Plant, Animal, and Microbial Research. Tell Us About Your Project. Expert Sequencing Services. With over 20 Years of Project Experience, We’re Sure We Can Help. With 10X Genomics Libraries. More Insight. Less Cost Discover More. Mass Spectrometry Services.

    The tools of chemical biology, genomics and data mining can yield insights into the metabolites of the microbiome.


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Microbial genomics and drug discovery Download PDF EPUB FB2

Microbial Genomics and Microbial genomics and drug discovery book Discovery [Dougherty, Thomas J., Projan, Steven J.] on *FREE* shipping on qualifying offers. Microbial Genomics and Drug Discovery. Exploring innovative routes of drug discovery in the postgenomic era, Microbial Genomics and Drug Discovery examines bioinformatic and genomic approaches for the identification, detection, selection, and validation of new antibacterial targets and vaccine candidates.

The book discusses potential pathways for effective infection control, inhibitionCited by: 5. Book Description. Exploring innovative routes of drug discovery in the postgenomic era, Microbial Genomics and Drug Discovery examines bioinformatic and genomic approaches for the identification, detection, selection, and validation of new antibacterial targets and vaccine candidates.

The book discusses potential pathways for effective infection control, inhibition of antibacterial resistance, and acceleration of the drug discovery process.

This comprehensive reference describes procedures to recognize common targets in various bacterial species for the design of broad-spectrum antibiotics and clearly illustrates the use of pathway tools in a genomics-based drug discovery project. Exploring innovative routes of drug discovery in the postgenomic era, Microbial Genomics and Drug Discovery examines bioinformatic and genomic approaches for the identification, detection, selection, and validation of new antibacterial targets and vaccine candidates.

The book discusses potential pathways for effective infection control, inhibition. Book Description: Exploring innovative routes of drug discovery in the postgenomic era, Microbial Genomics and Drug Discovery examines bioinformatic and genomic approaches for the identification, detection, selection, and validation of new antibacterial targets and vaccine candidates.

The pathway tools software and its role in antimicrobial drug discovery -- 5. Genomic strategies in antibacterial drug discovery -- 6. Genomics-based approaches to novel antimicrobial target discovery -- 7. Pathogenesis genes as novel targets -- 8. Application of genomics to the discovery of new drugs against tuberculosis -- 9.

Microbial genomics and drug discovery: exploring innovative routes of drug discovery in the postgenomic era The impact of microbial genomics on the development of Microbial genomics and drug discovery book antibiotics has been surprisingly minimal to date. GMGI is working to develop genomic programs that catalog microbes isolated from marine sanctuaries as well as from the deep sea.

Marine habitat offers a unique opportunity for research and drug discovery since it is largely unexplored. One goal is to identify key genetic mechanisms that can produce novel compounds such as antibiotics. Excerpt. On June 12the Institute of Medicine’s (IOM’s) Forum on Microbial Threats convened a public workshop in Washington, DC, to discuss the scientific tools and approaches being used for detecting and characterizing microbial species, and the roles of microbial genomics and metagenomics to better understand the culturable and unculturable microbial world around us.

Exploring innovative routes of drug discovery in the postgenomic era, "Microbial Genomics and Drug Discovery" examines bioinformatic and genomic approaches for the identification, detection, selection, and validation of new antibacterial targets and vaccine : Hardcover.

This Microbial Genomics And Drug Discovery book is just not ordinary book, you have after that it the world is in your hands. The benefit you get by reading this book will be information inside this publication incredible fresh, you will get information which is getting deeper anyone read a lot of information you will.

Jizhong Zhou is a Staff Scientist and science leader for the Microbial Genomics and Ecology section in the Environmental Sciences Division of Oak Ridge National Laboratory.

He is the author of more than 50 publications on molecular biology, microbial genomics, molecular evolution, microbial ecology, bioremediation, and theoretical ecology. Keywords:microbial genomics, antibiotic discovery, prokaryotic drug, genomics approach, genomics-based drug Abstract: The process of prokaryotic drug discovery has been a model of success for over fifty years, yet the number of exploited bacterial targets is a mere fraction, less than % of the potential targets (based on total number of.

The impact of genomics on antimicrobial drug discovery and toxicology Microbial Functional Genomics represents a timely summary of the principles, approaches, and applications at the forefront of this exciting and rapidly progressing by: He has extensive drug discovery, toxicology, and screening experience working for Abbott, Pharmacia, Monsanto, Searle, Ohio State University, and Cornell University.

Blomme has written over fifty journal articles and eight book chapters, and is a reviewer for multiple scientific journals in the fields of.

Get this from a library. Microbial genomics and drug discovery. [Thomas J Dougherty; Steve Projan;] -- This text examines bioinformatic and genomic approaches for the identification, detection, selection, and validation of new antibacterial targets and vaccine candidates.

Microbial Population Genomics and Ecology: A New Frontier Edward F. Delong Application of Genomics to Biocatalysis and Biodegradation Lawrence P. Wackett Enzyme Discovery and Microbial Genomics Robert M. Kelly and Keith R. Shockley Integration of Genomics in the Drug Discovery Process Jacques Ravel A Genomic Approach to Vaccine Development.

Together with the recent advances in microbial genomics and metagenomics, synthetic biology, fundamental understanding of natural product biosynthesis, and bioinformatics and analytical technologies, we are surely entering a New Golden Age of natural products drug discovery.

Download: Download high-res image (KB). Microbial Functional Genomics offers a timely summary of the principles, approaches, and applications. It presents a comprehensive review of microbial functional genomics, covering microbial Reviews: 1.

Introduction. Microbial natural products (MNPs) have been a major storehouse for drug discovery and development for several decades [1, 2].In fact, more than 20 active MNPs have been utilized as lead compounds, including anti-microbials, anti-virals, and cytotoxic and immunosuppressive compounds, mainly due to their structural novelty, diversity, and complexity.

Title: Microbial Genomics and Novel Antibiotic Discovery: New Technology to Search for New Drugs VOLUME: 8 ISSUE: 13 Author(s):Thomas J. Dougherty, John F. Barrett and Michael J. Pucci Affiliation:AI2 Antibacterial,Pfizer, Inc., Eastern Point Road MSGroton, CTUSA Keywords:microbial genomics, antibiotic discovery, prokaryotic drug, genomics approach, genomics-based drug.

This book presents the application of genomic tools to examine bacterial adaptation. The emphasis is on data analysis and interpretation. Much of the material is drawn from the recent, primary literature, which is the most powerful tool in the cutting-edge and fast-growing field of bacterial research.

Science Posted on Structural Genomics and Drug Discovery: Methods and Protocols focuses on high throughput structure determination methods and how they can be applied to lay the groundwork for structure aided drug methods and protocols that are described can be applied in any laboratory interested in using detailed structural information to advance the initial stages of drug discovery.

We are surely entering a New Golden Age of natural products drug discovery. Recent advances in microbial genomics and metagenomics have definitively revealed that the vast majority of earth’s biodiversity is yet to be exploited for natural products discovery (Charlop-Powers et al., ).

The pace of technical advancement in microbial genomics has been breathtaking. Sincewhen the first complete genome sequence of a free-living organism, Haemophilus influenzae, was.

Industrialization of this process provides a model for improving the efficiency of natural-product discovery. The application of advanced genomics and bioinformatics technologies is now poised to revolutionize natural-product discovery and lead a renaissance of interest in microorganisms as a source of bioactive compounds for drug development.

Microbial Genomics and Drug Discovery by Thomas J. Dougherty,Steven J. Projan Book Resume: Exploring innovative routes of drug discovery in the postgenomic era, Microbial Genomics and Drug Discovery examines bioinformatic and genomic approaches for the identification, detection, selection, and validation of new antibacterial targets and vaccine.

This chapter discusses the concepts of microbial genomics and pathogen discovery. The discussion begins with an overview of traditional efforts, followed by a brief description of the evolution of sequencing technologies. Finally, the chapter illustrates how the two fields began to intersect in the first few years of the 21st century.

The discoveries of Hepatitis C virus (HCV) and Human. This collection of diverse articles by the pioneers of modern genomics takes stock of the current state of the field and elucidates the contribution that sequencing genomes has made to our understanding of microbial metabolism and evolution.

Through twenty-eight thought-provoking chapters, the Price: $   The researchers first looked at microbial data available from The Cancer Genome Atlas, a database of the National Cancer Institute containing genomic and other information from thousands of patient tumors.

To the team’s knowledge, it was the largest effort ever undertaken to identify microbial DNA in human sequencing data. Proteomics and Functional Genomics inferring microbial physiology, pathogenicity, resistance from genomic sequences.

starting with the target identification and method of drug discovery, through the development of lead compounds, patent filings, drug refinement, clinical trials, regulatory approvals and marketing processes.

* the importance of advancing drug discovery and development to be of actual use in personalized medicine * the role of biomarkers, toxicogenomics and pharmacogenomics in accomplishing that.

They do this by detailing, in several very lucid chapters of background material, a refresher in modern genomics and microarray technologies.

Research and Discovery. Biomarker and Target Discovery Single-Cell Genomics; Microbial/Metagenomics; Gene Regulation; Data and Pipeline Management; CLC Genomics Workbench – QIAGEN CLC Genomics Workbench is a powerful solution that works for everyone, no matter the workflow.

Cutting-edge technology, unique featur. This contributed book comprehensively reviews mechanisms of microbial pathogenesis, host-pathogen interactions, drug resistance, and biofilm formation of prominent human pathogens and compares different animal models to investigate microbial pathogenesis and for anti-microbial drug discovery.

His main areas of research are microbial biodiversity, bioenergy, biopolymers, quorum sensing and quenching, and drug discovery.

He has published more than papers in scientific journals including Nature Biotechnology, Biotechnology Advances, and Bioresource Technology. He has authored 14 book. Genetics - Genetics - Microbial genetics: Microorganisms were generally ignored by the early geneticists because they are small in size and were thought to lack variable traits and the sexual reproduction necessary for a mixing of genes from different organisms.

After it was discovered that microorganisms have many different physical and physiological characteristics that are amenable to study. Citation: Huang T, Lin S. () Microbial Natural Products: A Promising Source for Drug Discovery.

J Appl Microbiol Biochem. Vol. 1 No. Traditionally, microbial natural products (NPs) have been identified as one of the most important source as well as the inspiration for drug discovery.

Over the time from s to. UF Drug discovery Instituted inThe Center for Natural Products, Drug Discovery and Development (CNPD3) is housed in the Department of Medicinal Chemistry at the University of Florida College of Pharmacy and is strategically complemented by affiliated faculty from the different colleges and departments across the university.

Current approaches to charting microbial metabolic pathways are expensive, tedious and time consuming, hindering the development of new applications such as vaccines or antimicrobial substances.

New tools are needed to build an accurate map of all the chemical reactions that take place in a particular strain of bacteria with no dead ends or. The centre for drug discovery and development was established in at the university with the goal to discover novel drugs to fight against life threatening infectious diseases including tuberculosis(TB), Acquired Immuno Deficiency syndrome (AIDS), Dengue and non-infectious diseases including cancer, diabetes etc., the centre has unique capabilities for antimycobacterial and antiviral drug.Microbial Genomics and Biotechnology Methods from molecular biology (recombinant DNA and DNA sequencing), bioinformatics, and cultivation-based microbiology are combined with those from industry and medicine to solve pressing societal needs (drug discovery and production, new products development, bioremediation, etc), as well as to untangle.One such technology is microbial genomics, which in recent years has had a considerable impact on the overall paradigm of antimicrobial discovery.

At the forefront of this technology was the high throughput sequencing and assembly of the Haemophilus influenzae genomic DNA sequence in 6 This landmark accomplishment was the first free.